2. No. 3 Marquette over No. 1 Kentucky, regional final, 2003

The 2003 tournament was about Kentucky, Arizona and everyone else. There was such little doubt about this that the pre-tourney chatter all focused on how unfair it was that the top two teams in the country would have to play in a regional semifinal (the ranking of No. 1 seeds began a year later because of this). So, of course, neither made it to the Final Four. Kentucky was riding a 23-game win streak before running into Dwyane Wade's Marquette team. The future NBA star's legend began that evening, as he dropped the fifth triple-double in NCAA tournament history (29/11/11). In retrospect it doesn't look like much of an upset. At the time, it was seismic. Kentucky's road to the title was never supposed to be in doubt. (A side note: Amazingly, Wade didn't make the all-tournament team.)